Auto‐Oxidation‐Induced Construction of Isatins from Glycine Derivatives. Issue 3 (8th February 2019)

• Record Type: Journal Article
• Authors: Min, Wenjian; Li, Haitao; Quan, Zhengjun; Yang, Caixia; Huo, Congde
• Is Part Of: Asian journal of organic chemistry. Volume 8:Issue 3(2019)
• Page Start: 335
• Page End: 338
• Publication Date: 2019-02-08
• Subjects: auto-oxidation -- isatins -- glycine derivatives -- oxygenation -- annulation; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.201900043
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: An oxygenation approach to isatins via an auto‐oxidation/intramolecular annulation tandem reaction of glycine derivatives is described. This transformation provides a metal‐free protocol for the preparation of isatin derivatives, which are important structural motifs widely found in organic molecules with various functions and privileged units for the synthesis of complex heterocycles. The reaction proceeds smoothly under mild reaction conditions and requires only Brønsted acid and oxygen. Abstract : Oxygen mask : An oxygenation approach to isatins via an auto‐oxidation/intramolecular annulation tandem reaction of glycine derivatives is described. This transformation provides a metal‐free protocol for the preparation of isatin derivatives, which are important structural motifs widely found in organic molecules with various functions and privileged units for the synthesis of complex heterocycles. The reaction proceeds smoothly under mild reaction conditions and requires only a Brønsted acid and oxygen.