Synthesis of the core structure of phalarine. Issue 7 (9th October 2018) - Douki, Kazuya
Abstract : Two new palladium-catalyzed reactions enabled the synthesis of the core structure of phalarine. Abstract : The core skeleton of phalarine was rapidly synthesised through novel palladium-catalysed dearomative spirocyclisation and a palladium-catalysed Wacker-carbonylative cyclisation cascade. The two key steps allowed for the efficient construction of a tricyclic propeller skeleton bearing contiguous tetrasubstituted carbon centres, within 3 steps from a topologically planar precursor.