Using automated glycan assembly (AGA) for the practical synthesis of heparan sulfate oligosaccharide precursors. Issue 7 (13th December 2018)

• Record Type: Journal Article
• Authors: Budhadev, Darshita; Saxby, Karinna; Walton, Julia; Davies, Gideon; Tyler, Peter C.; Schwörer, Ralf; Fascione, Martin A.
• Is Part Of: Organic & biomolecular chemistry. Volume 17:Issue 7(2019)
• Page Start: 1817
• Page End: 1821
• Publication Date: 2018-12-13
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob02756k
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Herein we report synthesis of complex heparan sulfate oligosaccharide precursors by automated glycan assembly using disaccharide donor building blocks. Abstract : Herein we report synthesis of complex heparan sulfate oligosaccharide precursors by automated glycan assembly using disaccharide donor building blocks. Rapid access to a hexasaccharide was achieved through iterative solid phase glycosylations on a photolabile resin using Glyconeer™, an automated oligosaccharide synthesiser, followed by photochemical cleavage and glycan purification using simple flash column chromatography.