Promising antifungal activity of Croton tricolor stem essential oil against Candida yeasts. Issue 3 (4th May 2019)

• Record Type: Journal Article
• Authors: Miranda, Fabrício Mendes; Braga do Nascimento Junior, Baraquizio; Aguiar, Rosane Moura; Pereira, Rafael Santos; De Oliveira Teixeira, Adonias; De Oliveira, Djalma Menezes; Lima, Edeltrudes de Oliveira; Oigman, Silvia Siag; de Rezende, Cláudia Moraes; Froldi, Guglielmina
• Is Part Of: Journal of essential oil research. Volume 31:Issue 3(2019)
• Page Start: 223
• Page End: 227
• Publication Date: 2019-05-04
• Subjects: Brazilian traditional medicine -- antifungal activity -- volatile oil composition -- terpenes -- phytoconstituents; Essences and essential oils -- Periodicals; Oils, Volatile -- Periodicals; Plant Oils -- Periodicals; 547.71
• DOI: 10.1080/10412905.2018.1539416
• Languages: English
• ISSNs: 1041-2905

Abstract

ABSTRACT: The aim of this research was to determine the phytoconstituents of the essential oil (EO) obtained from stems of Croton tricolor and to study its antifungal activity against several Candida species. The EO was extracted from C. tricolor stems by hydrodistillation with a Clevenger apparatus. This EO was characterized by four major components: epiglobulol, α-bisabolol, α-trans-bergamotol and β-caryophyllene. Microbiological assays were performed using the microdilution method in liquid medium to determine the minimum inhibitory concentration (MIC) for each Candida strain. EO concentrations from 1.0 to 1024 μg/mL inhibited the growth of all tested strains. Overall, the microbiological assays showed that C. tricolor EO has significant inhibitory activity against several Candida species. Thus, the C. tricolor stem EO is a promising natural product in the treatment of candidiasis.