Evaluation of various dose homogeneity indices for treatment of patients with cervix cancer using intensity-modulated radiation therapy technique. Issue 1 (9th August 2018)

• Record Type: Journal Article
• Authors: Atiq, Atia; Atiq, Maria; Iqbal, Khalid; Shamsi, Quratul Ain; Buzdar, Saeed Ahmad
• Is Part Of: Journal of radiotherapy in practice. Volume 18:Issue 1(2019)
• Page Start: 32
• Page End: 37
• Publication Date: 2018-08-09
• Subjects: cervix cancer, -- homogeneity index, -- integral dose, -- intensity-modulated radiotherapy, -- planning target volume; Radiotherapy -- Periodicals; 615.842005
• DOI: 10.1017/S1460396918000249
• Languages: English
• ISSNs: 1460-3969

Abstract

Abstract: Aim: This study is primarily aimed at the analysis of various dose homogeneity indices (HIs) essential for the evaluation of therapeutic plans by employing intensity-modulated radiation therapy (IMRT) on patients with cervix cancer. Also integral dose (ID) to healthy surrounding organs is computed. Materials and methods: Effectiveness of different HIs (A, B, C, D) was explored for IMRT plans using 15 MV photon beam. In total, 18 patients were selected at random for treatment of cervix cancer, and dose of 5, 040 cGy was delivered in 28 equal fractions. Results: The study was undertaken to compare four HI formulas and coefficient of determination between each set of HI was known by calculating R 2 value. Mean±SD of HI A, HI B, HI C and HI D were 1·12±0·02, 0·13±0·04, 0·10±0·02 and 0·99±0·03, respectively. Mean value of ID for rectum is 3·16 and for bladder is 10·3. Findings: Our data suggested that HI calculated using four formulas provided good plan quality. The results advocate that all the studied HIs can be effectively used for assessment of uniformity inside the target volume. However, values of HI C were closest to ideal value as compared with other three formulas; hence, it is considered a better measure to compute homogeneity of dose within target volume. The ID gives satisfactory results for surrounding normal tissues such as rectum and bladder and significant critical tissue sparing was achieved by using IMRT technique.