Latent tuberculosis infection and non-infectious co-morbidities: Diabetes mellitus type 2, chronic kidney disease and rheumatoid arthritis. (March 2019)

• Record Type: Journal Article
• Authors: Ugarte-Gil, Cesar; Carrillo-Larco, Rodrigo M.; Kirwan, Daniela E.
• Is Part Of: International journal of infectious diseases. Volume 80(2019)Supplement 1
• Page Start: S29
• Page End: S31
• Publication Date: 2019-03
• Subjects: Tuberculosis -- Diabetes mellitus type 2 -- Chronic kidney disease and Rheumatoid arthritis; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2019.02.018
• Languages: English
• ISSNs: 1201-9712

Abstract

Abstract: The prevalence of non-communicable diseases is increasing worldwide, which coincides with the persistence of infectious diseases including tuberculosis. These can synergistically affect individual and population health. Three non-communicable diseases that are relevant because of their associated morbidity, mortality and disability are type 2 diabetes mellitus, chronic kidney disease and rheumatoid arthritis. There is some evidence that patients with these conditions are at increased risk of acquiring latent tuberculosis infection (LTBI) and of this progressing to active disease. Unfortunately, evidence on accurate testing and effective prophylactic treatment in these populations is lacking. This review discusses current evidence and recommendations for management of LTBI in these patients.