Molecular investigation of the Pfmdr1 gene of Plasmodium falciparum isolates in Henan Province imported from Africa. Issue 3 (27th September 2018)

• Record Type: Journal Article
• Authors: Yang, Chengyun; Zhou, Ruimin; Liu, Ying; Li, Suhua; Qian, Dan; Zhao, Yuling; Zhang, Hongwei; Xu, Bianli
• Is Part Of: Parasitology. Volume 146:Issue 3(2019)
• Page Start: 372
• Page End: 379
• Publication Date: 2018-09-27
• Subjects: Africa, -- antimalarial drugs, -- Henan Province, -- malaria, -- Pfmdr1, -- Plasmodium falciparum; Parasitology -- Periodicals; Electronic journals; 616.96
• DOI: 10.1017/S0031182018001609
• Languages: English
• ISSNs: 0031-1820

Abstract

Abstract: Efficacious antimalarial drugs are important for malaria control and elimination, and continuous monitoring of their efficacy is essential. The prevalence and distribution of Pfmdr 1 were evaluated in African migrant workers in Henan Province. Among 632 isolates, 13 haplotypes were identified, NYSND (39.87%, 252/632), YYSND (2.85%, 18/632), NFSND (31.01%, 196/632), NYSNY (0.47%, 3/632), YFSND (13.77%, 87/632), NFSNY (0.32%, 2/632), YYSNY (2.06%, 13/632), YFSNY (0.16%, 1/632), N/Y YSND (1.90%, 12/632), N Y/F SND (6.17%, 39/632), N/Y Y/F SND (0.47%, 3/632), YYSN D/Y (0.16%, 1/632) and N/Y FSND (0.79%, 5/632). The highest frequency of NYSND was observed in individuals from North Africa (63.64%, 7/11), followed by South Africa (61.33%, 111/181), Central Africa (33.33%, 56/168), West Africa (28.94%, 68/235) and East Africa (27.03%, 10/37) ( χ 2 = 54.605, P < 0.05). The highest frequency of NFSND was observed in East Africa (48.65%, 18/37), followed by West Africa (39.14%, 92/235), Central Africa (26.79%, 45/168), South Africa (22.65%, 41/181) and North Africa (9.09%, 1/11) ( χ 2 = 22.368 P < 0.05). The mutant prevalence of codons 86 and 184 decreased. These data may provide complementary information on antimalarial resistance that may be utilized in the development of a treatment regimen for Henan Province.