Body mass index, height and risk of lymphoid neoplasms in a large United States cohort. Issue 6 (June 2013)

• Record Type: Journal Article
• Authors: Patel, Alpa V.; Diver, W. Ryan; Teras, Lauren R.; Birmann, Brenda M.; Gapstur, Susan M.
• Is Part Of: Leukemia & lymphoma. Volume 54:Issue 6(2013:Jun.)
• Page Start: 1221
• Page End: 1227
• Publication Date: 2013-06
• Subjects: Obesity -- body mass index -- lymphoma -- prospective cohort; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.3109/10428194.2012.742523
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: Results from epidemiologic studies examining associations between body size and risk of non-Hodgkin lymphoma (NHL) are inconsistent, and etiology may vary by histologic subtype of disease. Using Cox proportional hazards regression, multivariable relative risks (RRs) and 95% confidence intervals (CIs) were computed for associations of body mass index (BMI) and height with NHL in the prospective American Cancer Society Cancer Prevention Study-II Nutrition Cohort. From 1992 to 2007, 2074 incident cases of NHL were identified among 152 423 men and women. Obese individuals (BMI ≥ 30 kg/m 2 ) had 23% higher incidence of NHL (95% CI 1.08–1.40) compared to those with normal weight (BMI 18.5–< 25 kg/m 2 ). Height was positively associated with NHL (RR = 1.25, 95% CI 1.10–1.43, sex-specific quintile 5 vs. 1). BMI associations were strongest for diffuse large B-cell lymphoma. Height was most strongly associated with chronic lymphocytic leukemia/small lymphocytic lymphoma and to a lesser extent with multiple myeloma. These findings provide further evidence that body size may play a role in the etiology of NHL, which is of public health importance given the rapid rise in obesity worldwide.