Intradural extramidullary dorsal melanocytoma in the adult: Case report and review of the literature. (April 2019)

• Record Type: Journal Article
• Authors: Armocida, Daniele; Pesce, Alessandro; Berra, Luigi Valentino; Marzetti, Francesco; Antonelli, Manila; Santoro, Antonio
• Is Part Of: Journal of clinical neuroscience. Volume 62(2019)
• Page Start: 248
• Page End: 253
• Publication Date: 2019-04
• Subjects: MM meningeal melanocytoma -- CNS central nervous system -- IESM intradural extramedullary spinal melanocytomas -- GTR gross total resection -- RMC scale royal medical council scale -- TcMEPs transcranial motor evoked potentials -- SSEPs somatosensory evoked potentials -- EMG electromiography -- MRI magnetic resonance imaging -- EMA epithelial membrane antigen -- HMB-45 human black melanoma 45 protein -- WHO World Health Organization; Intradural extramedullary -- Melanocytoma -- Spinal -- MRI -- Melanoma; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2018.12.004
• Languages: English
• ISSNs: 0967-5868

Abstract

Abstract: Intradural Extramedullary Spinal Melanocytoma (IESM) is an extremely uncommon tumour arising from the spinal leptomeninges; both from a gross pathology and microscopic point of view it can mimick its malignant counterpart, the Melanoma. Such tumours are usually solitary, with a lower proliferating rate and without obvious SC invasion. Their common differential diagnoses include Spinal Schwannoma and Spinal Meningiomas since they share a significant amount of radiological similarities. It is a relatively benign condition which is, to date, with no more than 24 previously reported cases, yet widely unexplored and poorly understood. We report the detailed clinical history of a 60 years old individual suffering from IESM and, by means of a thorough Literature review, the most relevant features concerning the epidemiological issues, the clinical course, the radiological appearance, the surgical results and the typical gross and microscopic pathology of a cohort of previously reported cases of IESM are extensively discussed and systematically investigated through statistical analyses in order to add to the relevant Literature a dedicated work concerning this rare and enigmatic condition.