Predictors of survival outcome following radical gastrectomy for gastric cancer. Issue 1 (28th January 2019)

• Record Type: Journal Article
• Authors: Lui, Su‐Ann; Tan, Wee Boon; Tai, Bee Choo; Yong, Wei Peng; Mu, Yar Soe; Ti, Thiow Kong; Shabbir, Asim; So, Jimmy
• Is Part Of: ANZ journal of surgery. Volume 89:Issue 1/2(2019)
• Page Start: 84
• Page End: 89
• Publication Date: 2019-01-28
• Subjects: gastrectomy -- gastric cancer -- recurrence; Surgery -- Periodicals; 617.005
• DOI: 10.1111/ans.15011
• Languages: English
• ISSNs: 1445-1433

Abstract

Abstract : Background: Radical surgery with adjuvant therapy is now the standard treatment for locally advanced gastric cancer. However, the best regimen for adjuvant therapy remains controversial. We aim to determine the predictors of survival outcome of gastric cancer patients who underwent curative surgery with or without adjuvant therapy in our institution. Methods: All patients who received surgery for gastric cancer from years 2000 to 2015 were studied using a prospective gastric cancer database at the National University Hospital, Singapore. Results: A total of 405 patients underwent radical gastrectomy with curative intent. Seventy‐eight percent received extended lymphadenectomy (≥D1). R0 resection was achieved in 377 patients (93%) with 30‐day mortality rate of 1.7%. There was no significant difference in the complication rate between D1 and extended lymphadenectomy group. One hundred and forty‐five patients (36%) received adjuvant therapy. With a median follow‐up of 5.9 years, the 5‐year disease‐free survival for stage I to IV patients were 78%, 58%, 27% and 9%, respectively. Among the 141 patients with known recurrences, the first site of recurrence was 38% distant, 24% locoregional, 20% peritoneal and the rest were multiple sites. Stage of disease, adjuvant therapy, extent of lymphadenectomy, post‐operative complication and approach of surgery were independent risk factors for long‐term survival. Conclusions: Stage of disease, adjuvant therapy, extent of lymphadenectomy, post‐operative complication and approach of surgery are significant predictors for long‐term survival. Adequate and safe surgery to allow adjuvant therapy should be the goal of all surgeons for our gastric cancer patients. Abstract : This paper reported the patterns and predictors of recurrence of 405 patients with gastric cancer who underwent gastrectomy with or without adjuvant therapy from a prospective database in a tertiary hospital in Singapore over the past 13 years.