New tools for understanding coping and resilience. (6th February 2019)

• Record Type: Journal Article
• Authors: Baratta, Michael V.; Maier, Steven F.
• Is Part Of: Neuroscience letters. Volume 693(2019)
• Page Start: 54
• Page End: 57
• Publication Date: 2019-02-06
• Subjects: Stress -- Resilience -- Medial Prefrontal Cortex -- Serotonin -- Anxiety; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2017.09.049
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: Behavioral control that an organism has over a stressor potently modulates the impact of that stressor. Hypothesized circuits that detect and utilize information about the controllability of the stressor are intermixed within the prelimbic cortex. Viral-based genetic strategies can address the hypothesized function of these circuits in processing controllability information. Abstract: In humans, many of the factors determining vulnerability and resilience to the impact of an adverse event revolve around coping factors. This mini-review focuses on the neural mechanisms by which coping reduces the impact of adverse events, as studied in an animal model, and discusses some of the challenges of linking neural circuit activity with stressor outcome. We highlight several approaches for probing circuit function with cell-type and pathway-specificity that overcome some of the limitations of traditional neuroscience techniques and will likely yield a more detailed and comprehensive understanding of how the brain regulates stress-responsive structures when coping behaviors are engaged.