Resistin: A reappraisal. (March 2019)

• Record Type: Journal Article
• Authors: Acquarone, E.; Monacelli, F.; Borghi, R.; Nencioni, A.; Odetti, P.
• Is Part Of: Mechanisms of ageing and development. Volume 178(2019)
• Page Start: 46
• Page End: 63
• Publication Date: 2019-03
• Subjects: ACS acute coronary syndrome -- AD Alzheimer's disease -- ADSF adipose-tissue-specific secretory factor -- APO B apoliprotein B -- APO A1 apoliprotein A1 -- AS aortic stenosis -- AT aerobic training -- ATS atherosclerosis -- BMI body mass index -- CAD coronary artery disease -- cAMP cyclic adenosine monophosphate -- CAP-1 adenylyl cyclase-associated protein 1 -- CHD coronary heart disease -- CNS central nervous system -- CRP C-reactive protein -- CSF cerebrospinal fluid -- CVD cardiovascular disease CRF chronic renal failure -- DNC decorin -- DM2 diabetes mellitus 2 -- eNOS endothelial nitric oxide synthase -- ERK extracellular signal-regulated kinase -- ET-1 endothelin-1 -- FIZZ3 found in inflammatory zone 3 -- HCAECLs human coronary artery endothelial cell lines -- HDL high-density lipoprotein -- HMG-CoA 3-hydroxy-3-methylglutaryl-coenzyme A -- HMW high-molecular weight -- HF heart failure -- IGF-1R insulin growth factor 1 receptor -- IL-1 interleukin-1 -- ICAM-1 intercellular adhesion molecule-1 -- IR insufficient renal -- IRC insufficient respiratory chronic -- LDL low-density lipoprotein -- LDLR low-density lipoprotein receptor -- LMW low molecular weight -- MAPK mitogen-activated protein kinase -- MetS metabolic syndrome -- MMPs matrix metalloproteinases -- MPC-1 monocyte chemotactic protein-1 -- NAFLD non-alcoholic fatty liver disease -- NASH non-alcoholic steatohepatitis -- NF-kB nuclear factor kappa-light-chain-enhancer of activated β cells -- OA osteoarthritis -- PAI-1 plasminogen activator inhibitor-1 -- PBMC peripheral blood mononuclear cells -- PI3K/AKT phosphatidylinositol 3-kinase/protein kinase B -- PLC phospholipase C -- PPAR peroxisome proliferator-activated receptor -- PSCK9 proprotein convertase subtilisin/kexin type 9 -- RELM resistin-like molecule -- ROS reactive oxygen species -- RT resistance training -- SREBP2 sterol regulatory element-binding protein 2 -- TNF-α tumor necrosis factor-alpha -- TLR4 toll-like receptor 4 -- TRAF3 TNF receptor-associated factor 3 -- VCAM-1 vascular cell adhesion protein 1 -- VEGFR vascular endothelial growth factor -- VSMCs vascular smooth muscle cells -- JNKs c-Jun N-terminal kinases; Resistin -- Alzheimer's disease -- Metabolism -- Adipokines -- Aging; Aging -- Periodicals; Developmental biology -- Periodicals; Aging -- Periodicals; Developmental Biology -- Periodicals; Vieillissement -- Périodiques; Biologie du développement -- Périodiques; Aging; Developmental biology; Periodicals; 612.67
• DOI: 10.1016/j.mad.2019.01.004
• Languages: English
• ISSNs: 0047-6374

Abstract

Highlights: Several adipokines, including resistin, play a key role in the aging process. Resistin is associated with the onset of age-related chronic diseases. Resistin is a molecular link between biological aging and frailty. Resistin modulates metabolism and inflammation during aging. Abstract: From a biological point of view, aging can be considered a progressive inability of an organism to react to stress, maintain homeostasis, and survive unfavourable changes during post-maturational life. The expression of several adipokines changes during aging and for some changes, a role in the onset of chronic disease and frailty has been proposed. Among adipokines, resistin was shown in recent studies to play a key role in aging. Resistin is a small secreted protein that regulates glucose metabolism in mammalians. High resistin levels induce insulin resistance and exert proinflammatory effects. Consistently, resistin has been shown to play a pivotal role in various metabolic, inflammatory, and autoimmune diseases. Herein, the role of resistin as a molecular link between aging and age-related conditions was reviewed and the clinical implications of this knowledge discussed.