Dynamics in HIV‐DNA levels over time in HIV controllers. Issue 1 (10th January 2019)

• Record Type: Journal Article
• Authors: Avettand‐Fenoel, Véronique; Bayan, Tatiana; Gardiennet, Elise; Boufassa, Faroudy; Lopez, Pauline; Lecuroux, Camille; Noel, Nicolas; Trémeaux, Pauline; Monceaux, Valérie; Autran, Brigitte; Meyer, Laurence; Saez‐Cirion, Asier; Lambotte, Olivier; Rouzioux, Christine
• Other Names: Faller Jean‐Pierre investigator.; Eglinger Patricia investigator.; Roblot Pascal investigator.; Plainchamp M David investigator.; Aumaître Hugues investigator.; Malet Martine investigator.; Rouger Christine investigator.; Rémy Gérard investigator.; Isabelle Melle Kmiec investigator.; Delassus Jean‐Luc investigator.; Devidas Alain investigator.; Froguel Eric investigator.; Tassi Sylvie investigator.; Genet Philippe investigator.; Gerbe Juliette investigator.; Patey Olivier investigator.; Laurent Richier investigator.; Drobacheff Marie‐Christine investigator.; Proust Aurélie investigator.; Gil Helder investigator.; Gérard Laurence investigator.; Oksenhendler Eric investigator.; Lucht Frédéric investigator.; Ronat Véronique investigator.; Dupon Michel investigator.; Dutronc Hervé investigator.; Puil Séverine Le investigator.; Schmit Jean‐Luc investigator.; Decaux Nathalie investigator.; Molina Jean‐Michel investigator.; Lascoux Caroline investigator.; Parlier Sylvie investigator.; Bru Jean‐Pierre investigator.; Clavere Gaëlle investigator.; Delfraissy Jean‐François investigator.; Goujard Cécile investigator.; Bourdic Katia investigator.; Bergmann Jean‐François investigator.; Parrinello Maguy investigator.; Pichancourt Gilles investigator.; Welker Yves investigator.; Lafeuillade Alain investigator.; Gisèle Philip investigator.; Rapp Christophe investigator.; Lerondel Melle investigator.; de Truchis Pierre investigator.; Berthe Huguette investigator.; Jeantils Vincent investigator.; Mchangama Fatouma investigator.; Vittecoq Daniel investigator.; Bolliot Claudine investigator.; Consigny Paul Henri investigator.; Touam Fatima investigator.; Pialoux Gilles investigator.; le Nagat Sophie investigator.; Bouchaud Olivier investigator.; Honoré Patricia investigator.; Boué François investigator.; Raho‐Moussa Mariem investigator.; Weiss Laurence investigator.; Collias Lio investigator.; Salmon‐Céron Dominique investigator.; Pietri Marie‐Pierre investigator.; Blétry Olivier investigator.; Bornarel Dominique investigator.; Mortier Emmanuel investigator.; Feng Zeng investigator.; Lelièvre Jean‐Daniel investigator.; Katlama Christine investigator.; Dudoit Yasmine investigator.; Simon Anne investigator.; Lupin Catherine investigator.; Girard Pierre‐Marie investigator.; Pauchard Michèle investigator.; Abel Sylvie investigator.; Cabié André investigator.; Fialaire Pascale investigator.; Chennebault Jean‐Marie investigator.; Rehaiem M Sami investigator.; de Saint Martin Luc investigator.; Duthe M Jean‐Charles investigator.; Morlat Philippe investigator.; Caldato Sabrina investigator.; Neau Didier investigator.; Puil Séverine LE investigator.; Weinbreck Pierre investigator.; Makhloufi Djamila investigator.; Garnier Florence investigator.; Poizot‐Martin Isabelle investigator.; Fauche Olivia investigator.; Ivanova Alena investigator.; Yeni Patrick investigator.; Matheron Sophie investigator.; Cyndi Godard investigator.; Raffi François investigator.; Hüe Hervé investigator.; Perré Philippe investigator.; Roger Pierre Marie investigator.; Joulie Aline investigator.; Rosenthal Éric investigator.; Michelet Christian investigator.; Souala Faouzi investigator.; Ratajczak Maja investigator.; Partisani Marialuisa investigator.; Fischer Patricia investigator.; Bernard Louis investigator.; Nau Pascale investigator.; Marchou Bruno investigator.; Balsarin Florence investigator.; Verdon Renaud investigator.; Feret Philippe investigator.; Jacomet Christine investigator.; Piroth Lionel investigator.; Gohier Sandrine investigator.; Leclercq Pascale investigator.; Meybeck Agnés investigator.; Biekre Raphaël investigator.; May Thierry investigator.; Caron François investigator.; Debab Yasmine investigator.; Theron M David investigator.; Miailhes Patrick investigator.; Ogoudjobi M Stanislas investigator.; Mercié Patrick investigator.; Gatfosse Marc investigator.; Martinot Martin investigator.; Pachart Anne investigator.; Poubeau Patrice investigator.; Uludag Agnès investigator.; Arsac Philippe investigator.; Bouaraba Lydia investigator.; Szmania Isabelle De Lacroix investigator.; Richier M Laurent investigator.; Daneluzzi Vincent investigator.; Rouveix Elisabeth investigator.; Beck‐Wirth Geneviève investigator.; Romand Philippe investigator.; Blum Laurent investigator.; Deschaud Martine investigator.; Michau Christophe investigator.; Bernard Christian investigator.; Salaun Florence investigator.; Muller Philippe investigator.; Poinsignon Yves investigator.; Lepretre Annie investigator.; Deschaud Martine investigator.; Lambert Thierry investigator.; Hocqueloux Laurent investigator.; Philibert Patrick investigator.; Sow Mame Penda investigator.; Sotto Albert investigator.; Viard Jean‐Paul investigator.; Cros Agnés investigator.; Lavaissiere Marc De investigator.; Perfezou Pascale investigator.; Duthe M Jean Charles investigator.; Gaud Catherine investigator.; Niault Mathilde Aurore investigator.; Mouton‐Rioux Virginie investigator.; Talar Jean–Philippe investigator.; Mathilde Dupont investigator.; Natur M Stéphane investigator.; Hitoto Hikombo investigator.; Ibrahim M Ali Mahamadou investigator.;
• Is Part Of: Journal of the International AIDS Society. Volume 22:Issue 1(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-01-10
• Subjects: HIV reservoir -- HIV controllers -- total HIV‐DNA -- dynamics -- long‐term follow‐up; AIDS (Disease) -- Periodicals; HIV infections -- Periodicals; 616.9792005
• DOI: 10.1002/jia2.25221
• Languages: English
• ISSNs: 1758-2652

Abstract

Abstract: Introduction: HIV controllers (HIC) maintain viraemia at low levels without antiretroviral treatment and have small HIV reservoirs. Nevertheless, they are heterogeneous regarding their risk of infection progression. The study of reservoirs can help elucidate this control. This study aimed to explore the factors implicated in the pathogenesis of HIV infection that are potentially associated with HIV reservoirs and their dynamics in HIC. Methods: Individuals living with HIV included in the ANRS‐CODEX cohort with at least two HIV‐DNA measurements between 2009 and 2016 were selected. The total HIV‐DNA levels had been quantified prospectively from blood samples. Mixed‐effect linear models estimated the HIV‐DNA dynamics over time. Results: The median (interquartile range (IQR)) HIV‐DNA level was 1.5 (1.3 to 1.9) log copies/million peripheral blood mononuclear cells at inclusion (n = 202 individuals). These low levels showed heterogeneity among HIC. Lower levels were then associated with the protective HLA‐B*27/B*57 alleles and/or lower HIV‐RNA level at inclusion, negative hepatitis C virus serology, lower HIV‐suppressive capacity of specific CD8 T cells and lower levels of immune activation and inflammation. Interestingly, mathematical modelling of the dynamics of HIV‐DNA over time (840 measurements) showed that the number of infected cells decreased in 46% of HIC (follow‐up: 47.6 months) and increased in 54% of HIC. A multivariate analysis indicated that HLA‐B*27/B*57 alleles, a low level of HIV‐RNA and a low level of HIV‐DNA at inclusion were markers independently associated with this decrease. Conclusions: These results offer new insights into the mechanisms of long‐term control in HIC. In half of HIC, the decrease in HIV‐DNA level could be linked to tighter viral control and progressive loss of infected cells. These findings allow the identification of HIC with a low risk of progression who may not need treatment.