Novel, versatile and eco-compatible preparation of new 6-(1H-indol-3-yl)-2-oxo-4-aryl-1, 2, 3, 4-tetrahydropyrimidine-5-carbonitriles in water. (1st October 2013)

• Record Type: Journal Article
• Authors: Fatma, Shahin; Singh, Divya; Mishra, Priya; Singh, Pravin; Ankit, Preyas; Singh, J.
• Is Part Of: Journal of chemical research. Volume 37:Number 10(2013)
• Page Start: 642
• Page End: 644
• Publication Date: 2013-10-01
• Subjects: Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751913X13796840700061
• Languages: English
• ISSNs: 1747-5198

Abstract

A three-component, one-pot, simple and direct, highly efficient cyclocondensation method has been developed for the synthesis of 11 6-(1H-indol-3-yl)-2-oxo-4-aryl-1, 2, 3, 4-tetrahydropyrimidine-5-carbonitriles by combining an araldehyde with 3-(cyanoacetyl)-indole and urea in the presence of the cationic surfactant, CTAB and a catalytic amount of thiamine hydrochloride in water. A short reaction time, simple reaction conditions, ease of product isolation, and use of a cheap and readily available reusable catalyst make this method very attractive from an environmental and economic perspective.