Synthesis, antimalarial and antileishmanial activity of novel 13-benzyl-15, 16- bisnorlabdane derivatives. (1st November 2013)

• Record Type: Journal Article
• Authors: Salazar, Franklin; Quintero, Alberto; de Domínguez, Neira Gamboa; Concepción, Juan; Acosta, María; Tropper, Eleonora; Villamizar, José
• Is Part Of: Journal of chemical research. Volume 37:Number 11(2013)
• Page Start: 657
• Page End: 661
• Publication Date: 2013-11-01
• Subjects: Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751913X13794472538261
• Languages: English
• ISSNs: 1747-5198

Abstract

Twelve 13-benzyl-15, 16-bisnorlabdanes in which the C-13 and C-14 substituents are varied have been prepared from the naturally occurring labdane diterpene (+)-manool. These synthesised compounds were evaluated for antimalarial activity, in vitro as hemozoin formation inhibitors and in vivo against Plasmodium berghei. These derivatives were also assayed for antileishmanial activity against Leishmania mexicana.