Synthesis of novel indolizine, pyrrolo[1, 2-a] quinoline, and 4, 5-dihydrothiophene derivatives via nitrogen ylides and their antimicrobial evaluation. (1st September 2014)

• Record Type: Journal Article
• Authors: Gomha, Sobhi; Dawood, Kamal
• Is Part Of: Journal of chemical research. Volume 38:Number 9(2014)
• Page Start: 515
• Page End: 519
• Publication Date: 2014-09-01
• Subjects: Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751914X14067338307126
• Languages: English
• ISSNs: 1747-5198

Abstract

Treatment of 2-(2-bromoacetyl)-3H-benzo[f]chromen-3-one with pyridine, quinoline, and 2-methylquinoline afforded the corresponding pyridinium, quinolinium and 2-methylquinolinium bromides. The latter salts underwent [3 + 2] 1, 3-dipolar cycloaddition with some electron deficient acetylene and ethylene derivatives to give the corresponding indolizine and pyrrolo[1, 2-a]quinoline derivatives. Moreover, 2-(2-bromoacetyl)-3H-benzo[f]chromen-3-one reacted with arylidene cyanothioacetamides to afford the corresponding 2-amino-4, 5-dihydrothiophene-3-carbonitriles. The synthesised compounds were characterised based on their elemental analysis and spectral data. Antimicrobial activity of some of the synthesised compounds was evaluated.