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A facile synthesis of dispiro[indole-3, 2'-pyrrolidine-3, 5''-[1, 3]thiazolane] derivatives from 2, 3, 5-trisubstituted-4-thiazolidinones via 1, 3-dipolar cycloaddition reaction. (1st May 2014)
Record Type:
Journal Article
Title:
A facile synthesis of dispiro[indole-3, 2'-pyrrolidine-3, 5''-[1, 3]thiazolane] derivatives from 2, 3, 5-trisubstituted-4-thiazolidinones via 1, 3-dipolar cycloaddition reaction. (1st May 2014)
Main Title:
A facile synthesis of dispiro[indole-3, 2'-pyrrolidine-3, 5''-[1, 3]thiazolane] derivatives from 2, 3, 5-trisubstituted-4-thiazolidinones via 1, 3-dipolar cycloaddition reaction
A series of 2'', 3'', 4'-triaryl-1'-methyldispiro[indole-3, 2'-pyrrolidine-3', 5''-[1, 3]thiazolane]-2(1H), 4''-dione derivatives were successfully synthesised via a three-component 1, 3-dipolar cycloaddition reaction of 2, 3, 5-trisubstituted-4-thiazolidinones, isatin and sarcosine in refluxing toluene. Such a strategy would provide access to a fast one-pot synthesis of spiroheterocycle in high yields.