Synthesis and insecticidal evaluation of aryl pyrazole 5-fluorouracil compounds. (1st May 2014)

• Record Type: Journal Article
• Authors: Chen, Yue; Fu, Xiaodong; Mu, Haiping; Qin, Xiaofei; Wan, Rong
• Is Part Of: Journal of chemical research. Volume 38:Number 5(2014)
• Page Start: 272
• Page End: 279
• Publication Date: 2014-05-01
• Subjects: Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751914X13955977912102
• Languages: English
• ISSNs: 1747-5198

Abstract

Twenty eight aryl pyrazole derivatives containing 5-fluorouracil were designed and synthesised via the key intermediate 1-aryl-3-methyl-1H-pyrazole-5-carboxylic acid. The structures of target compounds were confirmed by 1 H NMR, FT-IR, EA and their insecticidal activities were evaluated. The bioassays revealed that aryl pyrazole derivatives containing 5-fluorouracil exhibited excellent insecticidal activities against Culex pipiens and Musca domestica at a concentration of 0.1%. Some compounds still showed good insecticidal activities even at a concentration of 0.05%.