An efficient three-component synthesis of trispiropyrrolidines derivatives through 1, 3-dipolar cycloaddition reaction. (1st October 2014)

• Record Type: Journal Article
• Authors: Feng, Guo-Liang; Li, Yue; Chen, Shao-Rui; Geng, Li-Jun; Wang, Kai-Fang
• Is Part Of: Journal of chemical research. Volume 38:Number 10(2014)
• Page Start: 589
• Page End: 592
• Publication Date: 2014-10-01
• Subjects: Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751914X14114758672870
• Languages: English
• ISSNs: 1747-5198

Abstract

The synthesis of novel trispiropyrrolidine derivatives has been achieved by a one-pot, three-component 1, 3-dipolar cycloaddition reaction of 3-aryl-5-arylmethylenespiro[indole-3′, 2-[1, 3]thiazolane]-2′(1H), 4-dione, isatin and sarcosine in refluxing toluene which produced the corresponding cycloadducts in good yields. The structures were determined by 1 H NMR, IR and elementary analysis.