An efficient synthesis of novel dihydrothiazol-2-yl-amides via cyclisation of propargylic carbamothioyl-amides. (1st March 2014)

• Record Type: Journal Article
• Authors: Saeedi, Mina; Goli, Fereshteh; Mahdavi, Mohammad; Sarihi, Pouria; Asadipour, Ali; Shafiee, Abbas; Foroumadi, Alireza
• Is Part Of: Journal of chemical research. Volume 38:Number 3(2014)
• Page Start: 131
• Page End: 133
• Publication Date: 2014-03-01
• Subjects: Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.3184/174751914X13899480812215
• Languages: English
• ISSNs: 1747-5198

Abstract

An efficient protocol is described for the versatile synthesis of novel dihydrothiazol-2-yl-amide derivatives via the regioselective 5-exo-dig heterocyclisation of N-propargyl carbamothioyl-amides in the presence of 1, 4-diazabicyclo[2.2.2]octane (DABCO) in refluxing ethanol. All products were obtained in good yields and short reaction time (10–30 min).