Disrupt toxicity testing: It's the dose rate that makes the poison. (10th August 2017)

• Record Type: Journal Article
• Authors: Hulla, Janis E; Hayes, A Wallace
• Is Part Of: Toxicology research and application. Volume 1(2017)
• Publication Date: 2017-08-10
• Subjects: Adverse outcome pathways -- toxicity testing -- disruptive technologies -- real-time imaging -- dose–response -- Frank R. Lautenberg Chemical Safety for the 21st Century Act; Toxicology -- Periodicals; 571.9505
• DOI: 10.1177/2397847317723571
• Languages: English
• ISSNs: 2397-8473

Abstract

Dimensions of time that are relevant to molecular mechanisms are not incorporated into conventional toxicity testing methodologies. Historically, this was due to technological limitations. These limitations no longer exist. Application of real-time imaging and chemical sensor technologies presents an opportunity to overcome the challenges that have stalled essential transformation of toxicity testing methodology.