41-Week Study of Progressive Diabetic Nephropathy in the ZSF1 fa/faCP Rat Model. (December 2018)

• Record Type: Journal Article
• Authors: Homer, Bruce L.; Dower, Ken
• Other Names: Heinz-Taheny Kathleen guest-editor.; Frazier Kendall guest-editor.; Ramaiah Shashi guest-editor.
• Is Part Of: Toxicologic pathology. Volume 46:Number 8(2018)
• Page Start: 976
• Page End: 977
• Publication Date: 2018-12
• Subjects: diabetic nephropathy -- ZSF1 rat model -- diabetic kidney disease; Pathology -- Periodicals; Toxicology -- Periodicals; Pathology; Toxicology; 615.9
• DOI: 10.1177/0192623318803278
• Languages: English
• ISSNs: 0192-6233

Abstract

This symposium synopsis summarizes key results from a 41-week study of diabetic nephropathy (DN) in the type 2 diabetic ZSF1 fa/fa CP rat model. During this study, we conducted longitudinal analysis of biomarkers, renal histopathology, ultrastructural assessment, renal quantitative image analysis, and transcriptome analysis of glomerular-enriched tissue. We concluded that there is translational value for using the ZSF1 rat model in mechanistic and therapeutic intervention efficacy studies for type 2 DN.