Advances in proton therapy in lung cancer. (14th July 2018)

• Record Type: Journal Article
• Authors: Vyfhuis, Melissa A.L.; Onyeuku, Nasarachi; Diwanji, Tejan; Mossahebi, Sina; Amin, Neha P.; Badiyan, Shahed N.; Mohindra, Pranshu; Simone, Charles B.
• Is Part Of: Therapeutic advances in respiratory disease. Volume 12(2018)
• Publication Date: 2018-07-14
• Subjects: proton therapy -- non-small cell lung cancer -- pencil beam scanning -- toxicities -- radiation therapy; Respiratory organs -- Diseases -- Periodicals; Respiratory agents -- Periodicals; Pulmonary pharmacology -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory System Agents -- therapeutic use -- Periodicals; Respiratory Tract Diseases -- drug therapy -- Periodicals; Lung Diseases -- drug therapy -- Periodicals; Appareil respiratoire -- Maladies -- Traitement -- Périodiques; Agents respiratoires -- Périodiques; Pharmacologie pulmonaire -- Périodiques; 616.2005
• DOI: 10.1177/1753466618783878
• Languages: English
• ISSNs: 1753-4658

Abstract

Lung cancer remains the leading cause of cancer deaths in the United States (US) and worldwide. Radiation therapy is a mainstay in the treatment of locally advanced non-small cell lung cancer (NSCLC) and serves as an excellent alternative for early stage patients who are medically inoperable or who decline surgery. Proton therapy has been shown to offer a significant dosimetric advantage in NSCLC patients over photon therapy, with a decrease in dose to vital organs at risk (OARs) including the heart, lungs and esophagus. This in turn, can lead to a decrease in acute and late toxicities in a population already predisposed to lung and cardiac injury. Here, we present a review on proton treatment techniques, studies, clinical outcomes and toxicities associated with treating both early stage and locally advanced NSCLC.