Extraskeletal osteosarcoma: A large series treated at a single institution. (30th January 2018)
- Record Type:
- Journal Article
- Title:
- Extraskeletal osteosarcoma: A large series treated at a single institution. (30th January 2018)
- Main Title:
- Extraskeletal osteosarcoma: A large series treated at a single institution
- Authors:
- Wang, Haotong
Miao, Ruoyu
Jacobson, Alex
Harmon, David
Choy, Edwin
Hornicek, Francis
Raskin, Kevin
Chebib, Ivan
DeLaney, Thomas F
Chen, Yen-Lin E - Abstract:
- Purpose: This study is to present a large cohort of extraskeletal osteosarcoma (ESOS) and evaluate prognostic factors and treatment options.Methods: Medical records were reviewed retrospectively for 41 patients with extraskeletal osteosarcoma that was diagnosed by pathology, and treated at our institution between 1960 and 2016. Kaplan-Meier analysis and Cox proportional hazards regression were used to identify variables that affect survival outcomes.Results: 41 patients were identified from 952 osteosarcomas. 32 patients had non-metastatic disease. Prognostic factors were identified by univariate analysis and multi-variate analysis. Surgery ( p <0.001), and surgery type ( p <0.001) both were shown to significantly affect overall survival (OS). Chemotherapy and radiation therapy (RT) did not show any significant effect on OS, local recurrence, or progression free survival as a whole. However for patients who had incomplete resection with residual tumor RT improved OS ( p =0.03). The survival curve for ESOS follows more closely that of non-rhabdomyosarcoma soft tissue sarcomas (NRSTS).Conclusions: ESOS is a very rare tumor. Attempt to achieve wide resection is the treatment of choice. However for patients who are not able to achieve complete resection, RT may improve OS. The behavior of ESOS more closely follows that of NRSTS than osteosarcoma of the bone.
- Is Part Of:
- Rare tumors. Volume 10(2018)
- Journal:
- Rare tumors
- Issue:
- Volume 10(2018)
- Issue Display:
- Volume 10, Issue 2018 (2018)
- Year:
- 2018
- Volume:
- 10
- Issue:
- 2018
- Issue Sort Value:
- 2018-0010-2018-0000
- Page Start:
- Page End:
- Publication Date:
- 2018-01-30
- Subjects:
- Extraskeletal osteosarcoma -- extraosseous osteosarcoma -- adjuvant therapy -- surgery
Rare diseases -- Periodicals
Tumors -- Periodicals
Neoplasms
Rare Diseases
Rare diseases
Tumors
Case Reports
Periodicals
Periodicals
616.994 - Journal URLs:
- http://www.ncbi.nlm.nih.gov/pmc/journals/1377/ ↗
http://bibpurl.oclc.org/web/71100 ↗
http://www.pagepress.org/journals/index.php/rt ↗
http://search.ebscohost.com/direct.asp?db=a9h&jid=%22B090%22&scope=site ↗
http://journals.sagepub.com/home/RTU ↗ - DOI:
- 10.1177/2036361317749651 ↗
- Languages:
- English
- ISSNs:
- 2036-3613
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD Digital store
- Ingest File:
- 9601.xml