Improved conditional imputation for linear regression with a randomly censored predictor. (February 2019)

• Record Type: Journal Article
• Authors: Atem, Folefac D; Sampene, Emmanuel; Greene, Thomas J
• Is Part Of: Statistical methods in medical research. Volume 28:Number 2(2019)
• Page Start: 432
• Page End: 444
• Publication Date: 2019-02
• Subjects: Bootstrap -- censored covariate -- complete case -- conditional imputation -- multiple imputation; Medicine -- Research -- Statistical methods -- Periodicals; Research -- Periodicals; Review Literature -- Periodicals; Statistics -- methods -- Periodicals; Médecine -- Recherche -- Méthodes statistiques -- Périodiques; 610.727
• DOI: 10.1177/0962280217727033
• Languages: English
• ISSNs: 0962-2802

Abstract

This article describes a nonparametric conditional imputation analytic method for randomly censored covariates in linear regression. While some existing methods make assumptions about the distribution of covariates or underestimate standard error due to lack of imputation error, the proposed approach is distribution-free and utilizes resampling to correct for variance underestimation. The performance of the novel method is assessed using simulations, and results are contrasted with methods currently used for a limit of detection censored design, including the complete case approach and other nonparametric approaches. Theoretical justifications for the proposed method are provided, and its application is demonstrated through a study of association between lipoprotein cholesterol in offspring and parental history of cardiovascular disease.