Optimizing the Cu-RDRP of N-(2-hydroxypropyl) methacrylamide toward biomedical applications. Issue 5 (13th December 2018)

• Record Type: Journal Article
• Authors: Raus, Vladimír; Kostka, Libor
• Is Part Of: Polymer chemistry. Volume 10:Issue 5(2019)
• Page Start: 564
• Page End: 568
• Publication Date: 2018-12-13
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/c8py01569d
• Languages: English
• ISSNs: 1759-9954

Abstract

Abstract : Aqueous Cu-RDRP of N -(2-hydroxypropyl) methacrylamide was optimized to achieve co(polymers) of low dispersity and controlled molecular weight at high conversions. Abstract : Aqueous Cu-RDRP of N -(2-hydroxypropyl) methacrylamide, a monomer with important biomedical applications, was optimized with respect to monomer conversion (82–99%), product dispersity (<1.25), and molecular weight control (up to 100 000). For this purpose, different chlorine-based initiators in conjunction with the CuCl/CuCl2 /PMDETA catalytic system were used. The utility of the optimized method in the biomedical field was demonstrated in the preparation of the poly(HPMA)-based copolymeric carrier having the anti-cancer drug doxorubicin conjugated through a pH-sensitive hydrazone linker.