B lymphocytes in anti-mycobacterial immune responses: Pathogenesis or protection?. (January 2019)

• Record Type: Journal Article
• Authors: Dyatlov, Alexander V.; Apt, Alexander S.; Linge, Irina A.
• Is Part Of: Tuberculosis. Volume 114(2019)
• Page Start: 1
• Page End: 8
• Publication Date: 2019-01
• Subjects: Mycobacterium tuberculosis -- B lymphocytes -- B cell follicles -- Lung -- Antibodies -- Cytokines; 616.995
• DOI: 10.1016/j.tube.2018.10.011
• Languages: English
• ISSNs: 1472-9792

Abstract

Abstract: The role of B cells and antibodies in tuberculosis (TB) immunity, protection and pathogenesis remain contradictory. The presence of organized B cell follicles close to active TB lesions in the lung tissue raises the question about the role of these cells in local host-pathogen interactions. In this short review, we summarize the state of our knowledge concerning phenotypes of B cells populating tuberculous lungs, their secretory activity, interactions with other immune cells and possible involvement in protective vs. pathogenic TB immunity.