Molecular and mechanical factors contributing to ductus arteriosus patency and closure. (23rd November 2018)

• Record Type: Journal Article
• Authors: Crockett, Stacey L.; Berger, Courtney D.; Shelton, Elaine L.; Reese, Jeff
• Is Part Of: Congenital heart disease. Volume 14:Number 1(2019)
• Page Start: 15
• Page End: 20
• Publication Date: 2018-11-23
• Subjects: ductus arteriosus -- oxygen -- patent ductus arteriosus -- prostaglandins; Congenital heart disease -- Periodicals; 616.1204305
• DOI: 10.1111/chd.12714
• Languages: English
• ISSNs: 1747-079X

Abstract

Abstract: Regulation of the ductus arteriosus, an essential fetal vessel connecting the pulmonary artery and aorta, is complex. Failure of this vessel to close after birth may result in a persistent left‐to‐right shunt through the patent ductus arteriosus, a condition associated with significant morbidities. Numerous factors contribute to the shift from fetal ductus patency to postnatal closure, requiring precise coordination of molecular cues with biomechanical forces and underlying genetic influences. Despite significant advances, questions remain regarding signaling dynamics and the natural time course of ductus closure, particularly in preterm neonates. This review highlights the contributions of early investigators and more recent clinician scientists to our understanding of the molecular and mechanical factors that mediate ductus patency and closure.