A comparison study of graphene-cyclodextrin conjugates for enhanced electrochemical performance of tyramine compounds. (1st April 2019)

• Record Type: Journal Article
• Authors: Zhu, Xuejing; Zhao, Jin; Jia, Tingting; Li, Shenghua; Li, Nan; Hou, Hongbiao; Zhong, Rong-Lin; Fan, Zhi; Guo, Minjie
• Is Part Of: Carbohydrate polymers. Volume 209(2019)
• Page Start: 258
• Page End: 265
• Publication Date: 2019-04-01
• Subjects: Graphene -- Cyclodextrin -- Chemical sensor -- Electrochemical -- Tyramine; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2019.01.023
• Languages: English
• ISSNs: 0144-8617

Abstract

Graphical abstract: Highlights: Fabricate graphene-CD conjugates by a simple method. Construct graphene-CD conjugates electrodes for enhanced electrochemical performance. Select four tyramine molecules as analytes for comparison study. Speculate several factors for achieving sensitivity and selectivity. Abstract: The present work describes the comparison of the abilities of graphene-cyclodextrin conjugates to enhance the electrochemical performance of four tyramine-related compounds. First, cyclodextrin (CD)-modified graphene conjugates were synthesized via the amine-epoxy reaction between graphene oxide (GO) and 6-deoxy-6-ethylenediamino- β -CD, followed byl -ascorbic acid reduction. The resulting conjugates were characterized using UV–vis spectroscopy, Fourier-transform infrared spectroscopy (FTIR), Raman spectroscopy, thermogravimetric analysis (TGA), X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Subsequently, for the comparative study, glass carbon electrode electrochemical sensors modified with these conjugates were prepared to detect four structurally similar analytes (tyramine, l -tyrosine, dopamine and levodopa). The sensor sensitivities of the modified electrodes were markedly higher than that of the bare electrode. Based on the results of the comparative study, several crucial factors for improving the performance of the electrodes were proposed, including the binding affinity and the binding orientation of CD toward analytes. The conclusions drawn in this study could provide theoretical foundation for the design and optimization of versatile electrochemical platforms with excellent properties.