New phomalone derivatives from the endolichenic fungus Cochliobolus kusanoi in Ny‐Alesund Arctic. Issue 3 (25th September 2018)

• Record Type: Journal Article
• Authors: Yang, Cailing; Xiao, Shiji; Yan, Song; Zhang, Maosheng; Cai, Qing; Fu, Shaobin; Meng, Qingfeng
• Is Part Of: Journal of the Chinese Chemical Society. Volume 66:Issue 3(2019)
• Page Start: 325
• Page End: 329
• Publication Date: 2018-09-25
• Subjects: Arctic -- biosynthetic pathway -- endolichenic fungus -- phomalone derivatives; Chemistry -- Periodicals; Electronic journals; 540.5
• DOI: 10.1002/jccs.201800220
• Languages: English
• ISSNs: 0009-4536

Abstract

Abstract : Natural products from endolichenic fungi, isolated from different lichen species, have been attracting much attention because of their potential to produce metabolites with activities and/or new structures. The filamentous fungus M227‐2 isolated from lichen in Ny‐Alesund Arctic showed significant anti‐microbial activity and was identified as Cochliobolus kusanoi based on 18S rDNA. Secondary metabolites of M227‐2 were investigated in order to exploit them as lead compounds for new antibiotics. Chemical investigation on M227‐2 led to the isolation of three phomalone derivatives (products1 –3) . Their structures were elucidated on the basis of their NMR and MS spectral data. Product2 was new, whereas products1 and3 were isolated for the first time from the species. The biosynthetic pathway is also proposed. Abstract : The filamentous fungus M227‐2 was isolated from lichen in Ny‐Alesund Arctic, which showed significant anti‐microbial activity and was identified as Cochliobolus kusanoi based on 18S rDNA. Chemical investigation on M227‐2 led to the isolation of three phomalone derivatives (product1 –3 ). Their structures were elucidated on the basis of their NMR and MS spectral data.