Vitamin E – The Next 100 Years. Issue 4 (14th December 2018)

• Record Type: Journal Article
• Authors: Khadangi, Fatemeh; Azzi, Angelo
• Other Names: Zingg Jean‐Marc guestEditor.
• Is Part Of: IUBMB life. Volume 71:Issue 4(2019)
• Page Start: 411
• Page End: 415
• Publication Date: 2018-12-14
• Subjects: vitamin E -- tocopherols -- nonantioxidant functions -- signal transduction -- gene expression; Biochemistry -- Periodicals; Molecular biology -- Periodicals; 572.8
• DOI: 10.1002/iub.1990
• Languages: English
• ISSNs: 1521-6543

Abstract

Abstract: α‐Tocopherol is the only tocopherol that has been shown to prevent the human deficiency disease Ataxia with Isolated Vitamin E Deficiency (AVED), and thus it is the only one that, for humans, can be called vitamin E. Vitamin E in addition to preventing AVED has documented immune boosting properties and an activity against nonalcoholic hepatosteatosis and low‐grade inflammation. Epidemiological studies indicating that vitamin E could prevent cardiovascular events, neurodegenerative disease, macular degeneration, and cancer were in general not confirmed by clinical intervention studies. Vitamin E and some of its metabolites modulate cell signaling and gene transcription. Future research is needed to achieve a better understanding of the molecular events leading to gene regulation by vitamin E, especially in its phosphorylated form. Isolation and characterization of the vitamin E kinase and vitamin E phosphate phosphatase will help in the understanding of cell regulation processes modulated by vitamin E. A clarification of the pathogenesis of AVED remains an important goal to be achieved. © 2018 IUBMB Life, 71(4):411–415, 2019