Alkylation of Allyl/Alkenyl Sulfones by Deoxygenation of Alkoxyl Radicals. Issue 12 (29th January 2019)

• Record Type: Journal Article
• Authors: Han, Jia‐Bin; Guo, Ao; Tang, Xiang‐Ying
• Is Part Of: Chemistry. Volume 25:Issue 12(2019)
• Page Start: 2989
• Page End: 2994
• Publication Date: 2019-01-29
• Subjects: alkenes -- alkoxyl radical -- deoxygenation -- photoredox catalysis -- radical alkylation; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201806138
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: A challenging deoxygenation of alkoxyl radicals from readily accessible alcohol derivatives was developed, affording facile synthesis of functionalized alkenes with good functional group tolerance under mild reaction conditions. Because alkoxyl radicals can easily undergo β‐fragmentations or hydrogen abstractions, this new strategy for deoxygenation of alkoxyl radicals is highly valuable. Moreover, mechanistic studies revealed that the electron‐neutral phosphine acts as the deoxygenation reagent. Abstract : A challenging deoxygenation of alkoxyl radicals from readily accessible alcohol derivatives is described, affording facile synthesis of synthetic valuable alkenes with good functional group tolerance under mild reaction conditions. Because alkoxyl radicals can easily undergo β‐fragmentations or hydrogen abstractions, this new strategy for deoxygenation of alkoxyl radicals is of high significance.