Genetic correlations between nicotine reinforcement‐related behaviors and propensity toward high or low alcohol preference in two replicate mouse lines. (10th September 2018)

• Record Type: Journal Article
• Authors: Weera, Marcus M.; Agim, Zeynep S.; Cannon, Jason R.; Chester, Julia A.
• Is Part Of: Genes, brain, and behavior. Volume 18:Number 3(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-09-10
• Subjects: alcohol -- conditioned taste aversion -- dorsal striatum -- free choice -- high‐performance liquid chromatography -- neurochemistry -- nicotine -- nicotinic acetylcholine receptors -- nucleus accumbens -- oral intake -- selectively bred mice; Behavior genetics -- Periodicals; Neurogenetics -- Periodicals; 616.8
• DOI: 10.1111/gbb.12515
• Languages: English
• ISSNs: 1601-1848

Abstract

Abstract : Common genetic factors may contribute to the high comorbidity between tobacco smoking and alcohol use disorder. Here, we assessed behavioral and biological effects of nicotine in replicate mouse lines selectively bred for high (HAP2/3) or low alcohol preference (LAP2/3). In Experiment 1, free‐choice (FC) oral nicotine and quinine intake were assessed in HAP2/3 and LAP2/3 mice. Effects of nicotinic acetylcholine receptor blockade by mecamylamine on nicotine intake in HAP2 mice were also examined. In Experiment 2, HAP2/3 and LAP2/3 mice were tested for differences in sensitivity to nicotine‐induced taste conditioning. In Experiment 3, the effects of a single nicotine injection on nucleus accumbens (NAc) and dorsal striatum monoamine levels in HAP2/3 and LAP2/3 mice were tested. In Experiment 1, HAP2/3 mice showed greater nicotine intake and intake ratio than LAP2/3 mice. There were no line differences in quinine intake. Mecamylamine reduced nicotine intake and intake ratio in HAP2 mice. In Experiment 2, HAP2/3 mice showed weaker nicotine‐induced conditioned taste aversion (CTA) compared with LAP2/3 mice. In Experiment 3, nicotine treatment increased NAc dopamine turnover across both HAP2/3 and LAP2/3 mouse lines. These results show that there is a positive genetic correlation between oral alcohol intake (high alcohol intake/preference selection phenotype) and oral nicotine intake and a negative genetic correlation between oral alcohol intake and sensitivity to nicotine‐induced CTA. Abstract : High alcohol preferring mouse lines show greater nicotine oral intake than low alcohol preferring lines.