Genome‐wide profiling of mRNA and lncRNA expression in dengue fever and dengue hemorrhagic fever. Issue 3 (2nd February 2019)

• Record Type: Journal Article
• Authors: Zhong, Xiao‐Lan; Liao, Xiao‐Ming; Shen, Fei; Yu, Hai‐Jian; Yan, Wen‐Sheng; Zhang, Yun‐Fang; Ye, Jia‐Jun; Lv, Zhi‐Ping
• Is Part Of: FEBS open bio. Volume 9:Issue 3(2019)
• Page Start: 468
• Page End: 477
• Publication Date: 2019-02-02
• Subjects: DEGs -- DElncRNAs -- dengue fever -- dengue hemorrhagic fever -- genome profiling -- integrated analysis; Molecular biology -- Periodicals; Cytology -- Periodicals; Life sciences -- Periodicals; Biological Science Disciplines -- Periodicals; Molecular Biology -- Periodicals; Cell Biology -- Periodicals; Cytology; Life sciences; Molecular biology; Periodicals; 572.805
• DOI: 10.1002/2211-5463.12576
• Languages: English
• ISSNs: 2211-5463

Abstract

Abstract : Dengue fever (DF) and dengue hemorrhagic fever (DHF) are recurrent diseases that are widespread in the tropics. Here, we identified candidate genes associated with these diseases by performing integrated analyses of DF (GSE51808 ) and DHF (GSE18090 ) microarray datasets in the Gene Expression Omnibus (GEO). In all, we identified 7635 differentially expressed genes (DEGs) in DF and 8147 DEGs in DHF as compared to healthy controls ( P < 0.05). In addition, we discovered 215 differentially expressed long non‐coding RNAs (DElncRNAs) in DF and 225 DElncRNAs in DHF. There were 1256 common DEGs and eight common DElncRNAs in DHF vs DF, DHF vs normal control, and DF vs normal control groups. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that signal transduction (false discovery rate = 8.33E‐10), 'toxoplasmosis', and 'protein processing in endoplasmic reticulum' were significantly enriched pathways for common DEGs. We conclude that the MAGED1, STAT1, and IL12A genes may play crucial roles in DF and DHF, and suggest that our findings may facilitate the identification of biomarkers and the development of new drug design strategies for DF and DHF treatment. Abstract : The genes encoding MAGED1, STAT1, and IL12A were identified as playing roles in dengue fever and dengue hemorrhagic fever. This finding may facilitate the identification of biomarkers and development of new drug design strategies for dengue fever and dengue hemorrhagic fever treatment.