Extracellular Vesicles: A Prevalent Tool for Microbial Gene Delivery?. Issue 1 (30th November 2018)

• Record Type: Journal Article
• Authors: Ben‐Hur, Sharon; Biton, Mirit; Regev‐Rudzki, Neta
• Other Names: Simpson Richard J. guestEditor.; Greening David W. guestEditor.
• Is Part Of: Proteomics. Volume 19:Issue 1/2(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-11-30
• Subjects: extracellular vesicles -- horizontal gene transfer; Proteins -- Separation -- Periodicals; Bioinformatics -- Periodicals; Proteomics -- Periodicals; Genomes -- Periodicals; Molecular genetics -- Periodicals; 572.605
• DOI: 10.1002/pmic.201800170
• Languages: English
• ISSNs: 1615-9853

Abstract

Abstract: Genetic plasticity of prokaryotic microbial communities is largely dependent on the ongoing exchange of genetic determinants by Horizontal Gene Transfer (HGT). HGT events allow beneficial genetic transitions to occur throughout microbial life, thus promoting adaptation to changing environmental conditions. Here, the significance of secreted vesicles in mediating HGT between microorganisms is discussed, while focusing on the benefits gained by vesicle‐mediated gene delivery and its occurrence under different environmental cues. The potential use of secreted DNA‐harboring vesicles as a mechanism of currently unresolved HGT events in eukaryotic microbes is further discussed.