Essential Fatty Acid Deficiency with SMOFlipid Reduction in an Infant with Intestinal Failure–Associated Liver Disease. Issue 3 (8th August 2018)

• Record Type: Journal Article
• Authors: Memon, Naureen; Hussein, Karen; Hegyi, Thomas; Herdt, Aimee; Griffin, Ian J.
• Is Part Of: JPEN, Journal of parenteral and enteral nutrition. Volume 43:Issue 3(2019)
• Page Start: 438
• Page End: 441
• Publication Date: 2018-08-08
• Subjects: Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; 615.85484
• DOI: 10.1002/jpen.1432
• Languages: English
• ISSNs: 0148-6071

Abstract

Abstract: Multicomponent lipid emulsions, such as SMOFlipid, contain intermediate amounts of essential fatty acids (EFAs) compared with traditional soybean–oil based lipid emulsions and 100% fish–oil lipid emulsions. We describe the development of moderate EFA deficiency (EFAD) and slow weight gain in an infant with intestinal failure–associated liver disease managed with SMOFlipid reduction (1 g/kg/d). Once SMOFlipid dosage was increased (2–3 g/kg/d), EFA levels normalized, adequate growth resumed, and the infant's cholestasis resolved. We recommend avoiding lipid reduction of SMOFlipid, which not only increases the risk for EFAD, but also is unnecessary given that cholestasis can be reversed on conventional doses of SMOFlipid.