Direct Metal‐Free Preparation of Functionalizable Polylactic Acid‐Ethisterone Conjugates in a One‐Pot Approach. Issue 5 (18th January 2019)

• Record Type: Journal Article
• Authors: Luo, Shi‐He; Wu, Yan‐Cheng; Cao, Liang; Lin, Jian‐Yun; Gao, Jian; Chen, Shui‐Xia; Wang, Zhao‐Yang
• Is Part Of: Macromolecular chemistry and physics. Volume 220:Issue 5(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-01-18
• Subjects: biomaterials -- copolymerization -- drug delivery systems -- functionalization of polymers -- polycondensation; Polymers -- Periodicals; Polymerization -- Periodicals; Synthetic products -- Periodicals; Macromolecules -- Periodicals; 547.7
• DOI: 10.1002/macp.201800475
• Languages: English
• ISSNs: 1022-1352

Abstract

Abstract: A series of polylactic acid (PLA) conjugates (PLA‐ES) are synthesized via direct melt polycondensation (DMP) of lactic acid (LA) with ethisterone (ES) in the presence of 0.3 wt% toluenesulfonic acid at 160 °C for 6 h. The drug content of PLA conjugates can be simply adjustable. Further functionalization via Click chemistry is also achieved to extend the biomedicine application of biopolymer based drug delivery. Abstract : A method for merging polymeric carrier preparation and chemical conjugation into one‐pot, via solvent‐ and metal‐free direct melt polycondensation, for functionalizable polylactic acid‐ethisterone (PLA‐ES) conjugates is developed.