Clinical and genetic associations with prostacyclin response in pulmonary arterial hypertension. (September 2018)

• Record Type: Journal Article
• Authors: Halliday, Stephen J.; Xu, Meng; Thayer, Timothy E.; Mosley, Jonathan D.; Sheng, Quanhu; Ye, Fei; Farber-Eger, Eric H.; Pugh, Meredith E.; Robbins, Ivan R.; Assad, Tufik R.; West, James D.; Brittain, Evan L.; Hemnes, Anna R.
• Is Part Of: Pulmonary circulation. Volume 8:Number 4(2018)
• Publication Date: 2018-09
• Subjects: pulmonary artery catheterization -- hemodynamics -- personalized medicine; Pulmonary circulation -- Periodicals; Pulmonary circulation; Electronic journals -- Sciences; Periodicals; 616.24005
• DOI: 10.1177/2045894018800544
• Languages: English
• ISSNs: 2045-8932

Abstract

Parenteral prostacyclin therapy is the most efficacious pharmacologic treatment for pulmonary arterial hypertension (PAH), but clinical response is variable. We sought to identify clinical, hemodynamic, and genetic associations with response to prostacyclin therapy. We performed a retrospective analysis of patients within a de-identified electronic health record and associated DNA biobank. Patients with PAH and a right heart catheterization (RHC) in the six months before initiation of a parenteral prostacyclin were included. Responders were defined a priori by attainment of World Health Organization (WHO) functional class (FC) 2 or better at the time of repeat RHC within two years. We performed exploratory analyses to identify genomic associations with prostacyclin response. Of 129 patients identified, 54 met our criteria for "responders." These patients were younger, more likely to be male, and were less likely to have connective tissue disease-related PAH. At follow-up, responders had improved hemodynamics, 6-min walk distance, and long-term survival. Baseline PA oxygen saturation (hazard ratio [HR] 0.568 [0.34–0.95]) and follow-up FC (HR = 2.57 [1.22–5.43]) were associated with survival. Prostacyclin responders were enriched in alleles related to cell development and circulatory system development and pathways related to aldosterone metabolism, cAMP signaling, and vascular smooth muscle contraction ( P < 0.001). Age at treatment initiation, WHO FC at short-term follow-up, and PA O2 % are associated with survival in patients with PAH exposed to parenteral prostacyclins. Exploratory genetic analysis yielded associations in biologically relevant pathways in the pathogenesis of PAH.