Fluorine‐Containing n‐6 and Angular and Linear n‐6‐n' (n,  n' = 5,  6,  7) Diaza‐Heterocyclic Scaffolds Assembled on Benzene Core in Unified Way. Issue 8 (27th February 2019)

• Record Type: Journal Article
• Authors: Prima, Darya O.; Makarov, Arkady G.; Bagryanskaya, Irina Yu.; Kolesnikov, Andrey E.; Zargarova, Leila V.; Baev, Dmitry S.; Eliseeva, Tatiana F.; Politanskaya, Larisa V.; Makarov, Alexander Yu.; Slizhov, Yuri G.; Zibarev, Andrey V.
• Is Part Of: ChemistrySelect. Volume 4:Issue 8(2019)
• Page Start: 2383
• Page End: 2386
• Publication Date: 2019-02-27
• Subjects: benzo-fused heterocycles -- boron heterocycles -- fluoroaromatics -- nitrogen heterocycles -- structure elucidation -- synthesis; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201803970
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: The title compounds, including hybrids (n ≠ n'), were assembled on benzene core in a unified way based on only one starting material C6 F5 NH2 and a limited number of simple substitution and condensation reactions. The heterocyclic moieties were 1, 3‐diazoles, 1, 2, 3‐triazoles, 1, 2, 5‐thia(selena)diazoles, 1.4‐diazines and 1, 5‐diazepines, as well as 1, 3, 2‐dioxaboroles. Representatives of all new scaffolds were characterized by XRD. Compounds synthesized are of biomedical interest in the context of apoptotic anticancer activity, and the 1, 2, 5‐thiadiazole/1, 3, 2‐dioxaborole hybrid also in that of neutron or/and proton capture therapy of cancer. New 1, 2, 5‐chalcogenadiazoles are protected forms of otherwise hardly accessible fluorine‐containing di‐ and tetra‐amines for further syntheses. Abstract : The title compounds were prepared in economic way based on the only starting material C6 F5 NH2 and a limited number of simple substitution and condensation reactions. They are of biomedical interest, e. g . in the context of apoptotic anticancer activity.