Polymeric Encapsulation of Turmeric Extract for Bioimaging and Antimicrobial Applications. Issue 5 (7th August 2018)

• Record Type: Journal Article
• Authors: Liu, Minghuan; Teng, Choon Peng; Win, Khin Yin; Chen, Yisong; Zhang, Xiaoyan; Yang, Da‐Peng; Li, Zibiao; Ye, Enyi
• Other Names: Loh Xian Jun guestEditor.; Li Zibiao guestEditor.
• Is Part Of: Macromolecular rapid communications. Volume 40:Issue 5(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-08-07
• Subjects: antibacterial -- bioimaging -- fluorescent curcumin -- polymer encapsulation -- turmeric extract; Macromolecules -- Periodicals; Polymers -- Periodicals; Chemistry -- Periodicals; 547.705
• DOI: 10.1002/marc.201800216
• Languages: English
• ISSNs: 1022-1336

Abstract

Abstract: As a herb of the ginger family, the turmeric plant has been used as spice and colorant in the Oriental countries. The rhizome part of the plant is rich in curcumin, which has been proven to be the main ingredient responsible for turmeric's biological effects. Most research endeavors have been upon the investigation of pharmaceutical activities of curcumin, yet the fluorescence of curcumin is a bit far from well‐studied. The major drawbacks associated with curcumin are its poor aqueous solubility and low stability. In this communication, the encapsulation of fluorescent turmeric extract into polymeric nanoparticles (NPs) for bioimaging and antibacterial applications is reported. Through poly(d, l ‐lactic‐co‐glycolic acid) (PLGA) encapsulation, solubility of curcumin is greatly increased, and the biodegradable nature of PLGA further enhances the biocompatibility of curcumin. These Cur‐PLGA NPs are successfully demonstrated to be efficient fluorescence probes for bioimaging, and promising for antibacterial application. Abstract : As the major ingredient in turmeric extract, curcumin exhibits strong fluorescence and potential antibacterial activity. Poor water solubility of curcumin is overcome by incorporating into poly(d, l ‐lactic‐co‐glycolic acid) (PLGA) nanoparticles (NPs). Bioimaging of live cells and the antibacterial effect against Escherichia coli and Staphylococcus aureus using curcumin‐incorporated PLGA NPs are successfully demonstrated.