Nutritional Intervention for Nonsurgical Head and Neck Cancer Patients Treated with Radiation Therapy: Results from a Prospective Stepped-Wedge Clinical Protocol. (3rd October 2018)

• Record Type: Journal Article
• Authors: Volpe, Stefania; Marvaso, Giulia; Alterio, Daniela; Ciardo, Delia; Sabbatini, Annarita; Zagallo, Emanuela; Valoriani, Filippo; Fanetti, Giuseppe; Ferrari, Annamaria; Cossu Rocca, Maria; Ansarin, Mohssen; Jereczek-Fossa, Barbara A.
• Is Part Of: Nutrition and cancer. Volume 70:Number 7(2018)
• Page Start: 1051
• Page End: 1059
• Publication Date: 2018-10-03
• Subjects: Cancer -- Periodicals; Nutrition -- Periodicals; Cancer; Nutrition; Periodicals; 616.9940654
• DOI: 10.1080/01635581.2018.1497187
• Languages: English
• ISSNs: 0163-5581

Abstract

Abstract: Aim: To evaluate the impact on weight loss (WL) of a standardized nutritional stepped-wedge protocol on consecutive head and neck cancer (HNC) patients treated with curative radiotherapy (RT). Methods: We prospectively collected data of patients followed by a trained dietitian and treated according to a pre-defined stepped-wedge protocol. Patients with swallowing defect at the baseline and WL >10% 3 months prior to the beginning of RT were excluded from the analysis. Nutritional status was assessed at the baseline and weekly during the course of RT. Fluid and caloric intake were assessed through a 24-h recall. Results: Between May 2010 and March 2011, 42 patients treated were evaluated. Median overall treatment time was 52.5 days. WL per CTCAE 4.03 was G0, G1 and G2 in 23 (55%), 14 (33%) and 5 (12%) patients, respectively. Thirty-five (83%) patients did not require enteral nutrition. About 90% of patients completed RT without interruption of oral feeding. Conclusions: Despite the high toxicity profile of curative RT in HN, we proposed a standardized stepped-wedge protocol allowing to prevent severe WL in most of our patients. Further larger prospective studies are warranted to validate our approach and to achieve consensus on nutritional intervention in this subset of patients.