Cryptococcal meningitis following umbilical cord blood transplantation, association between the occurrence of cryptococcal infection and tacrolimus discontinuation among allogeneic hematopoietic stem cell recipients. Issue 4 (April 2019)

• Record Type: Journal Article
• Authors: Mitsuki, Takashi; Kimura, Muneyoshi; Araoka, Hideki; Kageyama, Kosei; Takagi, Shinsuke; Yamamoto, Go; Nakamura, Shigeki; Miyazaki, Yoshitsugu; Uchida, Naoyuki; Yoneyama, Akiko; Taniguchi, Shuichi
• Is Part Of: Journal of infection and chemotherapy. Volume 25:Issue 4(2019:Apr.)
• Page Start: 289
• Page End: 292
• Publication Date: 2019-04
• Subjects: Micafungin breakthrough -- Tacrolimus -- Calcineurin inhibitor -- Cryptococcosis -- Allogeneic hematopoietic stem cell transplantation -- Umbilical cord blood transplantation; Chemotherapy -- Periodicals; Infection -- Periodicals; Communicable diseases -- Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1016/j.jiac.2018.09.006
• Languages: English
• ISSNs: 1341-321X

Abstract

Abstract: Few cases of cryptococcal infection following umbilical cord blood transplantation (UCBT) have been reported. We report a case, where cryptococcal infection occurred soon after rapidly reducing the dose of tacrolimus in a UCBT recipient who received micafungin prophylaxis during the early phase of transplantation. The etiology of cryptococcal infection following allogeneic hematopoietic stem cell transplantation (allo-HSCT), including UCBT, might be associated with rapid dose-reduction of calcineurin inhibitors, such as tacrolimus during early phase of allo-HSCT. To our knowledge, this is the first English-language report to describe in detail a case of cryptococcal meningitis with fungemia during early phase of UCBT.