Potential effects of dietary Maillard reaction products derived from 1 to 3 kDa soybean peptides on the aging ICR mice. (March 2019)

• Record Type: Journal Article
• Authors: He, Shudong; Yu, Min; Sun, Hanju; Zhang, Zuoyong; Zhu, Yuchen; Zhao, Jinlong; Tang, Mingming; Cao, Yanping
• Is Part Of: Food and chemical toxicology. Volume 125(2019)
• Page Start: 62
• Page End: 70
• Publication Date: 2019-03
• Subjects: Maillard reaction products -- Soybean peptides -- Aging mice -- Food intake -- Antioxidant activity -- Bacterial abundance; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2018.12.045
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Effects of Maillard reaction products derived from 1 to 3 kDa soybean peptides (MRPF3) on aging ICR mice were investigated. Seven animal groups were established for 5 weeks, including one normal group and six D-galactose (1000 mg kg −1 /day) treated groups. Aging control was D-galactose + saline solution, and positive controls were D-galactose + ascorbic acid (Vc) (400 mg kg −1 /day) and oligofructose (400 mg kg −1 /day), respectively, while the test groups are D-galactose + high (800 mg kg −1 /day), medium (400 mg kg −1 /day) and low (200 mg kg −1 /day) doses of MRPF3. Compared with the aging controls, food intake, body weights and organ indexes returned to normal after feeding with MRPF3, and the color of feces as well as the fluorescence intensity of urine increased. The content of malondialdehyde (MDA) in the liver significantly decreased with the intake of MRPF3, and the activities of SOD and GSH-Px and the total antioxidant capacity of serum significantly increased. The abundance ratio of Bacteroidetes and Firmicutes significantly decreased in MRPF3 groups, and the abundance of Lactobacillus significantly increased, while potentially pathogenic bacteria such as Porphyromonadaceae significantly decreased. Our results showed that MRPF3 might offer a potent retardation potential for aging. Graphical abstract: Image 1 Highlights: Maillard reaction products derived from 1 to 3 kDa soybean peptides (MRPF3) were made. Aging ICR mice were treated with MRPF3 at high, medium and low doses, respectively. Physiological indexes of aging mice returned to normality after feeding with MRPF3. Malondialdehyde content in liver decreased, antioxidant capacity of serum increased. Pathogenic bacterial were inhibited while beneficial ones proliferated.