Significance of immunohistochemical overexpression of cyclooxygenase-2 in overall and disease-free survival of oral squamous cell carcinoma patients. Issue 12 (24th January 2019)

• Record Type: Journal Article
• Authors: Adnan Ali, S M; Naeem, S; Mirza, Y; Zahid, N; Awan, M S
• Is Part Of: Journal of laryngology & otology. Volume 132:Issue 12(2018)
• Page Start: 1102
• Page End: 1109
• Publication Date: 2019-01-24
• Subjects: Cyclooxygenase 2, -- Oral Cavity, -- Immunohistochemistry, -- Squamous Cell Carcinoma, -- Prognosis, -- Disease-Free Survival; Otolaryngology -- Periodicals; 617.51
• DOI: 10.1017/S0022215118002207
• Languages: English
• ISSNs: 0022-2151

Abstract

Abstract: Objective: In Pakistan, oral cancer ranks as the most common malignancy in males and the second most common malignancy in females. Cyclooxygenase-2 has been explored as an agent of carcinogenesis in oral and other neoplasms. This study aimed to observe the expression of cyclooxygenase-2 in oral squamous cell carcinoma, and to correlate the expression with patients' clinical features and overall and disease-free survival. Methods: Immunohistochemistry for cyclooxygenase-2 was performed on a total of 100 oral squamous cell carcinoma formalin-fixed, paraffin-embedded blocks. Expression was correlated with patients' clinicopathological variables and overall and disease-free survival. Results: Cyclooxygenase-2 was overexpressed in 55 per cent of oral squamous cell carcinoma patients. Overexpression was correlated with overall survival ( p = 0.013) and disease-free survival ( p = 0.001) on univariate analysis. However, on multivariate analysis, cyclooxygenase-2 was associated with only disease-free survival ( p = 0.044) and not overall survival ( p = 0.208). Conclusion: Expression of cyclooxygenase-2 is associated with poorer overall survival and higher rates of recurrence in oral squamous cell carcinoma patients.