Epidemiology and economic impact of moderate and severe neurotrophic keratopathy in Italy. (12th July 2018)

• Record Type: Journal Article
• Authors: Stanisic, Sanja; Marocco, Alessia; Gallo, Anna; Rama, Paolo; Sacchetti, Marta; Rolando, Maurizio; Pocobelli, Augusto; Ceccuzzi, Roberto; Leonardi, Andrea; Mencucci, Rita; Pedrotti, Emilio; Postorino, Elisa; Mascia, Maurizio; Mazzamuto, Lucia R; Prisco, Luisanna; Van Nooten, Floortje; Berto, Patrizia
• Is Part Of: Global & regional health technology assessment. Volume 2018(2018)
• Publication Date: 2018-07-12
• Subjects: Neurotrophic keratopathy -- corneal diseases -- corneal sensitivity -- cornea/innervation -- keratitis/therapy -- cost analysis; Medical technology -- Evaluation -- Periodicals; Medical technology -- Economic aspects -- Periodicals; 610
• DOI: 10.1177/2284240318777150
• Languages: English
• ISSNs: 2284-2403

Abstract

Neurotrophic keratopathy is a rare corneal disease caused by impaired corneal innervation. There is a paucity of published evidence on neurotrophic keratopathy with no published studies on the economics of neurotrophic keratopathy in the Italian or international literature. This cost analysis aimed at assessing the economic impact of moderate (persistent epithelial defect) and severe (corneal ulcer without perforation) neurotrophic keratopathy from the perspective of the National Health Service and patients in Italy. Treatment algorithm and health resource use information were collected from a panel of nine experts from Italian centres specialized in ocular/corneal conditions. National ambulatory and inpatient hospital tariffs were applied to units of service, and Agenzia Italiana del Farmaco (AIFA) published prices to pharmaceuticals. Mean annual per patient cost was derived as an average cost weighted by the proportion of patients on each respective treatment and length of the treatment. The National Health Service + patient perspective additionally included patients' out-of-pocket expenses. The mean annual estimated National Health Service cost of treatment was €5167 (persistent epithelial defect) and €10, 885 (corneal ulcer without perforation) per patient. Costs were largely driven by ambulatory visits and hospital interventions. The mean annual estimated National Health Service + patient cost was €5731 (persistent epithelial defect) and €11, 478 (corneal ulcer without perforation) per patient, including cost of out-of-pocket expenses for pharmaceuticals and therapeutic contact lenses. Mean annual cost of neurotrophic keratopathy in Italy doubles with disease severity. Further research is warranted to provide more insight especially into societal costs.