Nanocrystals: A perspective on translational research and clinical studies. Issue 1 (24th December 2018)

• Record Type: Journal Article
• Authors: Jarvis, Maria; Krishnan, Vinu; Mitragotri, Samir
• Is Part Of: Bioengineering & translational medicine. Volume 4:Issue 1(2019)
• Page Start: 5
• Page End: 16
• Publication Date: 2018-12-24
• Subjects: clinical trials -- nanocrystals -- nanomedicine -- nanoparticles -- nanotherapeutics -- translational medicine; Bioengineering -- Periodicals; Drug development -- Periodicals; Drugs -- Testing -- Periodicals; 660.6
• DOI: 10.1002/btm2.10122
• Languages: English
• ISSNs: 2380-6761

Abstract

Abstract: Poorly soluble small molecules typically pose translational hurdles owing to their low solubility, low bioavailability, and formulation challenges. Nanocrystallization is a versatile method for salvaging poorly soluble drugs with the added benefit of a carrier‐free delivery system. In this review, we provide a comprehensive analysis of nanocrystals with emphasis on their clinical translation. Additionally, the review sheds light on clinically approved nanocrystal drug products as well as those in development.