In vitro activity of ceftaroline and ceftobiprole against methicillin-resistant Staphylococcus aureus with decreased susceptibility to vancomycin isolated in paediatric patients. (17th November 2018)

• Record Type: Journal Article
• Authors: Carnesecchi, Giulia; Lobello, Raffaele; Liggieri, Laura; Palmero, Candida; Pescetto, Luisa; Morelli, Patrizia; Castagnola, Elio; Bandettini, Roberto
• Is Part Of: Journal of chemotherapy. Volume 30:Number 6/8(2018)
• Page Start: 338
• Page End: 341
• Publication Date: 2018-11-17
• Subjects: Ceftaroline -- ceftobiprole -- methicillin-resistant Staphylococcus aureus -- minimal inhibitory concentrations -- paediatrics; Chemotherapy -- Periodicals; Drug Therapy -- Periodicals; 615.58
• DOI: 10.1080/1120009X.2018.1522473
• Languages: English
• ISSNs: 1120-009X

Abstract

Abstract : Minimal inhibitory concentrations (MIC, mg/l) of ceftaroline and ceftobiprole were evaluated over 70 methicillin-resistant Staphylococcus aureus (MRSA) strains with vancomycin MIC ≥1 isolated in a paediatric hospital. The proportion of non-wild-type strains (MIC > epidemiological cut off) was 18% for ceftobiprole and 64% for ceftaroline. Only 1.4% of strains was resistant to ceftobiprole, and none to ceftaroline. These results are worrisome, since show the presence of non-negligible proportions of MRSA strains with high MIC values for ceftaroline and ceftobiprole in a setting where both drugs were never used.