Synthesis, X-ray structure and in vitro cytotoxicity of trans-diammineplatinum(II) complexes of selenones, trans-[Pt(NH3)2(selenone)2](NO3)2. (15th January 2019)

• Record Type: Journal Article
• Authors: Alhoshani, Ali; Seliman, Adam A.A.; Altoum, Ali Osman; Abuelizz, Hatem A.; Ahmad, Saeed; Altaf, Muhammad; Omer, Khalid H.; Sohail, Manzar; Isab, Anvarhusein A.
• Is Part Of: Polyhedron. Volume 158(2019)
• Page Start: 234
• Page End: 240
• Publication Date: 2019-01-15
• Subjects: Transplatin -- Heterocyclic selenones -- In vitro cytotoxicity -- X-ray structure; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2018.09.010
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: Trans platinum(II) complexes of selenones having the general formula, trans- [Pt(NH3 )2 (selenone)2 ](NO3 )2 have been synthesized and characterized using elemental analysis, IR, and NMR ( 1 H & 13 C) spectroscopy. The crystal structure of one of them, trans- [Pt(NH3 )2 (PrImSe)2 ](NO3 )2 was determined by single crystal X-ray diffraction analysis. The in vitro cytotoxicity of the complexes were investigated against two human cancer cell lines, HeLa and MDA-231. Abstract: Seven trans platinum(II) complexes of selenones having the general formula, trans- [Pt(NH3 )2 (selenone)2 ](NO3 )2 have been synthesized and characterized using elemental analysis, IR, and NMR ( 1 H & 13 C & 77 Se) spectroscopy. The crystal structure of one of them, trans- [Pt(NH3 )2 (PrImSe)2 ](NO3 )2 (5 ) was determined by single crystal X-ray diffraction analysis. The platinum atom in the complex cation adopts a distorted square planar geometry. The spectroscopic data particularly, a significant upfield shift in 77 Se NMR indicated the coordination of selenone ligands to platinum(II). The in vitro cytotoxicity of these complexes as well as of cisplatin was investigated using MTT assay against two human cancer cell lines, HeLa (cervical cancer cells) and MDA-231 (human breast cancer cells). The IC50 values showed promising cytotoxicity for the prepared platinum(II) complexes, which in the case of1, 4 and6 is higher as compared to cisplatin.