A Single-Centre Experience on the Management of Adenosarcoma: A Successful Report of an Integrated Medical and Surgical Approach. (15th June 2018)

• Record Type: Journal Article
• Authors: Nannini, Margherita; Dondi, Giulia; Santini, Donatella; De Leo, Antonio; Dei Tos, Angelo Paolo; Zamagni, Claudio; Saponara, Maristella; Gatto, Lidia; Nigro, Concetta; Bertaccini, Paola; Zompatori, Maurizio; De Iaco, Pierandrea; Perrone, Anna Myriam; Pantaleo, Maria Abbondanza
• Is Part Of: Clinical medicine insights. Oncology. Volume 12(2018)
• Publication Date: 2018-06-15
• Subjects: Adenosarcoma -- epirubicin and ifosfamide -- multidisciplinary management -- sarcomatous overgrowth -- endometriosis -- biphasic tumours; Oncology -- Periodicals; 616.994005
• DOI: 10.1177/1179554918782477
• Languages: English
• ISSNs: 1179-5549

Abstract

Adenosarcomas are the rarest form of uterine sarcomas, and clinical experience with their management is still limited. Here, we reported 7 patients with uterine adenosarcoma referred to our institution, focusing on main pathologic features, their medical history, and long-term follow-up. Among these patients, we provided a detailed description of the medical history of a 49-year-old woman with advanced uterine adenosarcoma with sarcomatous overgrowth who presented a brilliant radiologic and pathologic response after 3 cycles of epirubicin and ifosfamide, ultimately achieving an extraordinary long-term outcome through an integrated surgical and medical approach. Our single-centre experience would suggest that aggressive uterine adenosarcomas with sarcomatous overgrowth are sensitive to standard epirubicin and ifosfamide and that an integrated approach, both medical and surgical, could be considered in clinical practice, again emphasizing the relevant role of multidisciplinary management for this extremely rare disease.