Serological response to influenza vaccination among adults hospitalized with community‐acquired pneumonia. Issue 2 (17th December 2018)

• Record Type: Journal Article
• Authors: Pratt, Caroline Quinn; Zhu, Yuwei; Grijalva, Carlos G.; Wunderink, Richard G.; Mark Courtney, D.; Waterer, Grant; Levine, Min Z; Jefferson, Stacie; Self, Wesley H.; Williams, Derek J.; Finelli, Lynn; Bramley, Anna M.; Edwards, Kathryn M.; Jain, Seema; Anderson, Evan J.
• Is Part Of: Influenza and other respiratory viruses. Volume 13:Issue 2(2019)
• Page Start: 208
• Page End: 212
• Publication Date: 2018-12-17
• Subjects: Influenza -- Periodicals; Respiratory infections -- Periodicals; Virus diseases -- Periodicals; Influenza, Human -- Periodicals; Respiratory Tract Diseases -- Periodicals; Virus Diseases -- Periodicals; Grippe -- Périodiques; Appareil respiratoire -- Infections -- Périodiques; Maladies à virus -- Périodiques; 616.203
• DOI: 10.1111/irv.12622
• Languages: English
• ISSNs: 1750-2640

Abstract

Abstract : Ninety‐five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction (PCR) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology was performed. After vaccination, seropositive (≥1:40) hemagglutination antibody titers (HAI) were achieved in 55% to influenza A(H1N1)pdm09, 58% to influenza A(H3N2), 77% to influenza B (Victoria), and 74% to influenza B (Yamagata) viruses. Sixty‐six (69%) patients seroconverted (≥4‐fold HAI rise) to ≥1 strain. Failure to seroconvert was associated with diabetes, bacterial detection, baseline seropositive titers for influenza B (Yamagata), and influenza vaccination in the previous season.